Marzulli and Maibachs Dermatotoxicology, 7th Edition

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As transdermal patches become more widely prescribed, it is important that clinicians understand: a the common causes of skin reactions with these medications; b how to minimize these reactions; and c how to manage the signs and symptoms. Here we review published data for skin reactions with patch medications approved within the past decade. Overall, the most common application site signs and symptoms appear to be localized redness erythema or itching, sometimes accompanied by swelling edema.


Most are localized to the area of application, and resolve spontaneously within several days following patch removal. Discontinuations due to these types of event are infrequent, ranging from 1. Based on expert opinion, the majority of these skin reactions would be a form of irritant contact dermatitis, with infrequent cases of allergic contact dermatitis. These types of reactions usually cause minimal pain or discomfort to the patient, and are unlikely to be of medical concern.

Signs and symptoms of irritant contact dermatitis may be minimized by rotation of the application site, careful removal of the patch, and appropriate use of moisturizers and topical corticosteroids.

In conclusion, the potential advantages of transdermal patches usually outweigh any additional skin issues; however, further research into treatment and management strategies is required. Unable to display preview. Download preview PDF. Skip to main content.

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Advertisement Hide. Skin tolerability associated with transdermal drug delivery systems: an overview. Review First Online: 27 November This is a preview of subscription content, log in to check access. Levin C, Maibach HI. Transdermal drug delivery system: an overview. Google Scholar. The Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. Modeling transdermal drug release. Adv Drug Deliv Rev. Transdermal delivery of drugs for urologic applications: basic principles and applications.

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Clinical benefits associated with a transdermal patch for dementia. Eur Neurol Rev. Transderm Scop Patch scopolamine 1.

Parsippany, NJ: Novartis. February Accessed October Exelon Patch rivastigmine transdermal system : How does the Exelon Patch work? Accessed April Murphy M, Carmichael AJ. Transdermal drug delivery systems and skin sensitivity reactions.

Book Marzulli And Maibachs Dermatotoxicology 7Th Edition

Incidence and management. Am J Clin Dermatol. Holdiness MR. A review of contact dermatitis associated with transdermal therapeutic systems.

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Contact Dermatitis. Adverse dermatologic reactions to transdermal drug delivery systems. Other Editions 2. Friend Reviews. To see what your friends thought of this book, please sign up. To ask other readers questions about Marzulli and Maibach's Dermatotoxicology , please sign up. Be the first to ask a question about Marzulli and Maibach's Dermatotoxicology. Lists with This Book. This book is not yet featured on Listopia. Community Reviews. Showing Rating details. All Languages. More filters.

Book Marzulli And Maibachs Dermatotoxicology 7Th Edition

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Dihydroxydiphenyl was concluded to be a contact allergen with insignificant or questionable contact allergenic potential, based on human case reports with no correlating animal data. Information on Registered Substances comes from registration dossiers which have been assigned a registration number.